Primary amebic meningoencephalitis and the biology of Naegleria fowleri.

نویسنده

  • D T John
چکیده

fJ:!��:!� :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: Treatme.�t ................................................................................................................. . EPIDEMIOLOGY AND ECOLOGY ......................................................................... . Geographic Distribution ....... .. ....................... ............................................................. . Environmental Isolations ........................................................................................... . Animal Infection ...................................................................................................... .. Control and Prevention ............................................................................................ .. PHYSIOLOGY/METABOLISM ................................................................................. . Nutrition and Growth ............................................................................................... . Cell Difj"erentiation .................................. ...................................................... .......... .. Macromolecular Composition .... .. ... ......................................................................... .. Cell Membrane and Agglutination ........................................................................... . Respiratory Metabolism ....................... ............... ....................................................... . VIRULENCE AND IMMUNITY ............................................................................... . Mechanisms of Pathogenesis ..................................................................................... . Resistance and Susceptibility ................ .................................................................... .. Immunization and Protection .................................................................................. .. CONCLUDING REMARKS ....................................................................................... .

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منابع مشابه

Primary Amebic Meningoencephalitis Caused by Naegleria fowleri, Karachi, Pakistan

We report 13 cases of Naegleria fowleri primary amebic meningoencephalitis in persons in Karachi, Pakistan, who had no history of aquatic activities. Infection likely occurred through ablution with tap water. An increase in primary amebic meningoencephalitis cases may be attributed to rising temperatures, reduced levels of chlorine in potable water, or deteriorating water distribution systems.

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841Estimation of Undiagnosed Neuroinfectious Deaths with the Epidemiologic Pattern of Primary Amebic Meningoencephalitis Caused by Naegleria fowleri

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Successful treatment of an adolescent with Naegleria fowleri primary amebic meningoencephalitis.

Naegleria fowleri is a thermophilic, free-living ameba that causes primary amebic meningoencephalitis. The infections are nearly always fatal. We present the third well-documented survivor of this infection in North America. The patient's survival most likely resulted from a variety of factors: early identification and treatment, use of a combination of antimicrobial agents (including miltefosi...

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Activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis.

Inhalation of fresh water containing the free-living ameba Naegleria fowleri may lead to a potentially fatal infection known as primary amebic meningoencephalitis. Amphotericin B is the only agent with established clinical efficacy in the treatment of primary amebic meningoencephalitis in humans, but therapy with this drug is often associated with adverse effects on the kidneys and other organs...

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Fatal Naegleria fowleri Meningoencephalitis, Italy

We report the first case of primary amebic meningoencephalitis in Italy, in a 9-year-old boy. Clinical course was fulminant, and diagnosis was made by identifying amebas in stained brain sections and by indirect immunofluorescence analysis. Naegleria fowleri was characterized as genotype I on the basis of polymerase chain reaction test results.

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عنوان ژورنال:
  • Annual review of microbiology

دوره 36  شماره 

صفحات  -

تاریخ انتشار 1982